Article
COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.
The Journal of clinical investigation - 2 Apr 2018
Xie Yuanyuan, Cao Zhen, Wong Elissa Wp, Guan Youxin, Ma Wenfu, Zhang Jenny Q, Walczak Edward G, Murphy Devan, Ran Leili, Sirota Inna, Wang Shangqian, Shukla Shipra, Gao Dong, Knott Simon Rv, Chang Kenneth, Leu Justin, Wongvipat John, Antonescu Cristina R, Hannon Gregory, Chi Ping, Chen Yu
Abstract excerpt
Aberrant activation of MAPK signaling leads to the activation of oncogenic transcriptomes. How MAPK signaling is coupled with the transcriptional response in cancer is not fully understood. In 2 MAPK-activated tumor types, gastrointestinal stromal tumor and melanoma, we found that ETV1 and other Pea3-ETS transcription factors are critical nuclear effectors of MAPK signaling that are regulated through protein...
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