Article
The Monoclonal Anti-CD157 Antibody Clone SY11B5, Used for High Sensitivity Detection of PNH Clones on WBCs, Fails to Detect a Common Polymorphic Variant Encoded by BST-1.
Cytometry. Part B, Clinical cytometry - 1 Jul 2018
Blaha Johanna, Schwarz Klaus, Fischer Claudia, Schauwecker Peter, Höchsmann Britta, Schrezenmeier Hubert, Anliker Markus
Abstract excerpt
BACKGROUND: CD157, encoded by BST-1, has been described as a useful flow cytometric marker for the analysis of paroxysmal nocturnal hemoglobinuria (PNH) as it is a glycosylphosphatidylinositol (GPI)-linked molecule highly expressed on normal monocytes and neutrophils. We and others observed isolated CD157 signal dropouts during intended PNH analysis. We hypothesize that these negative populations occur due to an...
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