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Article

Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries.

Journal of diabetes research - 1 Jan 2017

Lenoir Olivia, Gaillard François, Lazareth Hélène, Robin Blaise, Tharaux Pierre-Louis

Abstract excerpt

OBJECTIVE: Indirect evidence suggests a role for heme oxygenase-1 (HO-1) in limiting diabetic vasculopathy. The goal of this study was to assess the role of HO-1 in the development of microvascular lesions within glomeruli during diabetes mellitus using a mouse model with specific alteration of the Hmox1 gene. APPROACH AND RESULTS: The effects of Hmox1 haploinsufficiency were studied as a means of assessing the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29359167
DOI: 10.1155/2017/9603924
PMCID: PMC5735626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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