Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus.

Diabetes/metabolism research and reviews - 1 Jan 2000

Miller-Lotan Rachel, Herskowitz Yehuda, Kalet-Litman Shiri, Nakhoul Farid, Aronson Doron, Zoabi Roaa, Asaf Roy, Ben-Izhak Ofer, Sabo Edmond, Lim Sai-Kiang, Baumann Heinz, Berger Franklin G, Levy Andrew P

Abstract excerpt

BACKGROUND: The human haptoglobin (Hp) gene is polymorphic with two functional classes of alleles, denoted 1 and 2. We have demonstrated in three longitudinal studies and several cross-sectional studies that the Hp genotype is an independent risk factor for diabetic vascular disease. These studies have presented a compelling argument that diabetic individuals homozygous for the Hp 1 allele are at decreased risk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Experimental
Share to Diabetic Angiopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Haptoglobins

Share to Hypertrophy

Share to Kidney

Share to Mice, Knockout

Source

Identifiers

PMID: 15852445
DOI: 10.1002/dmrr.556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus.PMID 15852445Read ↗

Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus.Semantic proximity Read ↗

Haptoglobin genotype is a determinant of survival and cardiac remodeling after myocardial infarction in diabetic mice.Semantic proximity Read ↗

The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.Semantic proximity Read ↗

Hypothesis--haptoglobin genotype and diabetic nephropathy.Semantic proximity Read ↗

Association between haptoglobin gene variants and diabetic nephropathy: haptoglobin polymorphism in nephropathy susceptibility.Semantic proximity Read ↗

Is it time to screen for the haptoglobin genotype to assess the cardiovascular risk profile and vitamin E therapy responsiveness in patients with diabetes?Semantic proximity Read ↗

In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease.Semantic proximity Read ↗

Haptoglobin genotype is a regulator of reverse cholesterol transport in diabetes in vitro and in vivo.Semantic proximity Read ↗

Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.Semantic proximity Read ↗

The Haptoglobin genotype predicts cardio-renal mortality in type 1 diabetes.Semantic proximity Read ↗

The Goto Kakizaki rat: Impact of age upon changes in cardiac and renal structure, function.Semantic proximity Read ↗

Initial Characterization of a Rat Model of Diabetic NephropathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.