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Curcumin sensitizes hepatocellular carcinoma to 5-fluorouracil chemotherapy via the PLIN2-mediated lipid droplet metabolic pathway

2026-06-18

Abstract excerpt

<title>Abstract</title> <p> Resistance to 5-fluorouracil (5-FU) remains a major challenge in the treatment of hepatocellular carcinoma (HCC). PLIN2-regulated lipid droplet (LD) accumulation has been implicated in chemoresistance, but the role of curcumin in modulating this process remains unclear. In this study, we integrated WGCNA with the GSE42318 dataset to identify PLIN2 as a hub gene associated with 5-FU re...

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Literature Corpus work
67b5af15-c4ad-5903-9002-0529aaf93859
DOI
10.21203/rs.3.rs-9713546/v1
Open publication

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Curcumin sensitizes hepatocellular carcinoma to 5-fluorouracil chemotherapy via the PLIN2-mediated lipid droplet metabolic pathwayDOI 10.21203/rs.3.rs-9713546/v1
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