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Article

Clinical implications of cancer gene mutations in patients with chronic lymphocytic leukemia treated with lenalidomide.

Blood - 19 Apr 2018

Takahashi Koichi, Hu Boyu, Wang Feng, Yan Yuanqing, Kim Ekaterina, Vitale Candida, Patel Keyur P, Strati Paolo, Gumbs Curtis, Little Latasha, Tippen Samantha, Song Xingzhi, Zhang Jianhua, Jain Nitin, Thompson Philip, Garcia-Manero Guillermo, Kantarjian Hagop, Estrov Zeev, Do Kim-Anh, Keating Michael, Burger Jan A, Wierda William G, Futreal P Andrew, Ferrajoli Alessandra

Abstract excerpt

Lenalidomide is clinically active in chronic lymphocytic leukemia (CLL), but its effectiveness in the context of the CLL mutational landscape is unknown. We performed targeted capture sequencing of 295 cancer genes in specimens from 102 CLL patients with treatment-naïve disease (TN patients) and 186 CLL patients with relapsed/refractory disease (R/R patients) who received lenalidomide-based therapy at our...

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Identifiers

PMID: 29358183
DOI: 10.1182/blood-2017-11-817296
PMCID: PMC5909764

Genes

KRAS
MGA
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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