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Article

Modulation of apolipoprotein L1-microRNA-193a axis prevents podocyte dedifferentiation in high-glucose milieu.

American journal of physiology. Renal physiology - 1 May 2018

Mishra Abheepsa, Ayasolla Kamesh, Kumar Vinod, Lan Xiqian, Vashistha Himanshu, Aslam Rukhsana, Hussain Ali, Chowdhary Sheetal, Marashi Shoshtari Shadafarin, Paliwal Nitpriya, Popik Waldemar, Saleem Moin A, Malhotra Ashwani, Meggs Leonard G, Skorecki Karl, Singhal Pravin C

Abstract excerpt

The loss of podocyte (PD) molecular phenotype is an important feature of diabetic podocytopathy. We hypothesized that high glucose (HG) induces dedifferentiation in differentiated podocytes (DPDs) through alterations in the apolipoprotein (APO) L1-microRNA (miR) 193a axis. HG-induced DPD dedifferentiation manifested in the form of downregulation of Wilms' tumor 1 (WT1) and upregulation of paired box 2 (PAX2)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29357419
DOI: 10.1152/ajprenal.00541.2017
PMCID: PMC6031922

Genes

APOL1
PAX2
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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