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Article

Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly.

PLoS pathogens - 28 Mar 2008

Appel Nicole, Zayas Margarita, Miller Sven, Krijnse-Locker Jacomine, Schaller Torsten, Friebe Peter, Kallis Stephanie, Engel Ulrike, Bartenschlager Ralf

Abstract excerpt

Persistent infection with the hepatitis C virus (HCV) is a major risk factor for the development of liver cirrhosis and hepatocellular carcinoma. With an estimated about 3% of the world population infected with this virus, the lack of a prophylactic vaccine and a selective therapy, chronic hepatitis C currently is a main indication for liver transplantation. The establishment of cell-based replication and virus...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18369481
DOI: 10.1371/journal.ppat.1000035
PMCID: PMC2268006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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