Article
Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly.
PLoS pathogens - 28 Mar 2008
Appel Nicole, Zayas Margarita, Miller Sven, Krijnse-Locker Jacomine, Schaller Torsten, Friebe Peter, Kallis Stephanie, Engel Ulrike, Bartenschlager Ralf
Abstract excerpt
Persistent infection with the hepatitis C virus (HCV) is a major risk factor for the development of liver cirrhosis and hepatocellular carcinoma. With an estimated about 3% of the world population infected with this virus, the lack of a prophylactic vaccine and a selective therapy, chronic hepatitis C currently is a main indication for liver transplantation. The establishment of cell-based replication and virus...
Topics
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- Fluorescent Antibody Technique, Indirect
- Hepacivirus
- Hepatitis C Antigens
- Humans
- Mutation
- Protein Structure, Tertiary
- RNA, Viral
- Viral Core Proteins
- Viral Nonstructural Proteins
- Viral Proteins