Article
Frizzled receptors activate a novel JNK-dependent pathway that may lead to apoptosis.
Current biology : CB - 8 Jan 2002
Lisovsky Mikhail, Itoh Keiji, Sokol Sergei Y
Abstract excerpt
Extracellular Wnt ligands and their receptors of the Frizzled family control cell fate, proliferation, and polarity during metazoan development. Frizzled signaling modulates target gene expression through a beta-catenin-dependent pathway, functions to establish planar cell polarity in Drosophila epithelia, and activates convergent extension movements and intracellular Ca(2+) signaling in frog and fish embryos....
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