A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma.

doi:10.1158/1078-0432.CCR-17-2243

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Article

A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2018

Gómez Soledad, Garrido-Garcia Alícia, Garcia-Gerique Laura, Lemos Isadora, Suñol Mariona, de Torres Carmen, Kulis Marta, Pérez-Jaume Sara, Carcaboso Ángel M, Luu Betty, Kieran Mark W, Jabado Nada, Kozlenkov Alexey, Dracheva Stella, Ramaswamy Vijay, Hovestadt Volker, Johann Pascal, Jones David T W, Pfister Stefan M, Morales La Madrid Andrés, Cruz Ofelia, Taylor Michael D, Martin-Subero Jose-Ignacio, Mora Jaume, Lavarino Cinzia

Abstract excerpt

Purpose: The classification of medulloblastoma into WNT, SHH, group 3, and group 4 subgroups has become of critical importance for patient risk stratification and subgroup-tailored clinical trials. Here, we aimed to develop a simplified, clinically applicable classification approach that can be implemented in the majority of centers treating patients with medulloblastoma.Experimental Design: We analyzed 1,577...

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PMID: 29351917
DOI: 10.1158/1078-0432.CCR-17-2243

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