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Article

Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice.

American journal of physiology. Cell physiology - 1 Apr 2018

Gao Junyuan, Minogue Peter J, Beyer Eric C, Mathias Richard T, Berthoud Viviana M

Abstract excerpt

The lens is an avascular organ whose function and survival depend on an internal circulation system. Cx46fs380 mice model a human autosomal dominant cataract caused by a mutant lens connexin. In these mice, fiber cell connexin levels and gap junction coupling are severely decreased. The present studies were conducted to examine components of the lens circulation system that might be altered and contribute to the...

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Source

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Identifiers

PMID: 29351411
DOI: 10.1152/ajpcell.00277.2017
PMCID: PMC5966789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice.PMID 29351411Read ↗

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