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Article

Connexin46fs380 Causes Progressive Cataracts

8 Aug 2014

Abstract excerpt

PURPOSE: Although many connexin46 (Cx46) mutants have been linked to inherited human cataracts, there are no adequate animal models for their study. The current experiments were designed to characterize the consequences of expression of one such mutant, Cx46fs380, in the mouse lens. METHODS: Mice expressing Cx46fs380 were generated by a knockin strategy. Levels and distribution of specific proteins were analyzed...

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PMID: 25103261
DOI: 10.1167/iovs.14-15012

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Connexin46fs380 Causes Progressive CataractsPMID 25103261Read ↗

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