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Article

Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter.

Scientific reports - 18 Jan 2018

Kuypers K P C, de la Torre R, Farre M, Xicota L, de Sousa Fernandes Perna E B, Theunissen E L, Ramaekers J G

Abstract excerpt

MDMA exerts its main effects via the serotonergic system and the serotonin transporter. The gene coding for this transporter determines the expression rate of the transporter. Previously it was shown that healthy individuals with the short allelic variant ('s-group') of the 5-HTTLPR-polymorphism displayed more anxiety and negative mood, and had a lower transcriptional efficiency compared to individuals who are...

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Identifiers

PMID: 29348651
DOI: 10.1038/s41598-018-19618-1
PMCID: PMC5773595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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