Article
FYN promotes mesenchymal phenotypes of basal type breast cancer cells through STAT5/NOTCH2 signaling node.
Oncogene - 1 Apr 2018
Lee Ga-Hang, Yoo Ki-Chun, An Yoojeong, Lee Hae-June, Lee Minyoung, Uddin Nizam, Kim Min-Jung, Kim In-Gyu, Suh Yongjoon, Lee Su-Jae
Abstract excerpt
Basal type breast cancer is the most aggressive and has mesenchymal features with a high metastatic ability. However, the signaling node that determines the basal type features in breast cancer remains obscure. Here, we report that FYN among SRC family kinases is required for the maintenance of basal type breast cancer subtype. Importantly, FYN enhanced NOTCH2 activation in basal type breast cancer cells through...
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