Article
SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer.
Oncotarget - 29 Dec 2015
Gururajan Murali, Cavassani Karen A, Sievert Margarit, Duan Peng, Lichterman Jake, Huang Jen-Ming, Smith Bethany, You Sungyong, Nandana Srinivas, Chu Gina Chia-Yi, Mink Sheldon, Josson Sajni, Liu Chunyan, Morello Matteo, Jones Lawrence W M, Kim Jayoung, Freeman Michael R, Bhowmick Neil, Zhau Haiyen E, Chung Leland W K, Posadas Edwin M
Abstract excerpt
FYN is a SRC family kinase (SFK) that has been shown to be up-regulated in human prostate cancer (PCa) tissues and cell lines. In this study, we observed that FYN is strongly up-regulated in human neuroendocrine PCa (NEPC) tissues and xenografts, as well as cells derived from a NEPC transgenic mouse model. In silico analysis of FYN expression in prostate cancer cell line databases revealed an association with the...
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