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Article

Pik3ca is required for mouse uterine gland development and pregnancy.

PloS one - 1 Jan 2018

Chang Hye Jin, Shin Hee Sung, Kim Tae Hoon, Yoo Jung-Yoon, Teasley Hanna E, Zhao Jean J, Ha Un-Hwan, Jeong Jae-Wook

Abstract excerpt

The PI3K/AKT signaling pathway plays a critical role in the maintenance of equilibrium between cell survival and apoptosis. The Pik3ca gene is mutated in a range of human cancers. It has been found to be oncogenic, and mutations lead to constitutive activation of the PI3K/AKT pathway. The expression patterns of PIK3CA proteins in the uterus of mice during early pregnancy indicate that it may play a role in the...

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Identifiers

PMID: 29346447
DOI: 10.1371/journal.pone.0191433
PMCID: PMC5773209

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PGR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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