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Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy

1 Dec 2017

Abstract excerpt

Abstract: Acute myeloid leukemia (AML) is a clonal disorder of myeloid progenitors characterized by the acquisition of chromosomal abnormalities, somatic mutations, and epigenetic changes that determine a consistent degree of biological and clinical heterogeneity. Advances in genomic technologies have increasingly shown the complexity and heterogeneity of genetic and epigenetic alterations in AML. Among the...

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Share to Acute Myeloid Leukemia Research
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PMID: 29343972
DOI: 10.2147/ott.s145971

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