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Clinical developments in epigenetic-directed therapies in acute myeloid leukemia

9 Mar 2020

Abstract excerpt

Acute myeloid leukemia (AML) is a highly heterogeneous disease arising from acquired genetic and epigenetic aberrations which stifle normal development and differentiation of hematopoietic precursors. Despite the complex and varied biological underpinnings, induction therapy for AML has remained fairly uniform over 4 decades and outcomes remain poor for most patients. Recently, enhanced understanding of the...

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PMID: 32150613
DOI: 10.1182/bloodadvances.2019001245

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