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Article

Inhibitors of LSD1 as a potential therapy for acute myeloid leukemia

14 Apr 2016

Abstract excerpt

INTRODUCTION: Epigenetic dysregulation plays a critical role in the pathogenesis of acute myeloid leukemia (AML). Alterations in histone methylation lead to aberrant silencing of expression of multiple genes involved in tumor suppression and cell cycling, resulting in myeloid maturation arrest and proliferation of early myeloid progenitors. One promising approach targeting chromatin regulatory proteins is...

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Identifiers

PMID: 27077938
DOI: 10.1080/13543784.2016.1175432

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