Article
An Autoimmune Disease-Associated Risk Variant in the TNFAIP3 Gene Plays a Protective Role in Brucellosis That Is Mediated by the NF-κB Signaling Pathway.
Journal of clinical microbiology - 1 Apr 2018
Lou Lixin, Bao Wanguo, Liu Xianjun, Song Hongxiao, Wang Yang, Zhang Kaiyu, Gao Wenjing, Li Haijun, Tu Zhengkun, Wang Shaofeng
Abstract excerpt
Naturally occurring functional variants (rs148314165 and rs200820567, collectively referred to as TT>A) reduce the expression of the tumor necrosis factor alpha-induced protein 3 (TNFAIP3) gene, a negative regulator of NF-κB signaling, and predispose individuals to autoimmune disease. In this analysis, we conducted a genetic association study of the TT>A variants in 1,209 controls and 150 patients with...
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