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Article

Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital.

The Journal of antimicrobial chemotherapy - 1 May 2018

Kociolek Larry K, Ozer Egon A, Gerding Dale N, Hecht David W, Patel Sameer J, Hauser Alan R

Abstract excerpt

Background: Clostridium difficile strain DH/NAP11/106, a relatively antibiotic-susceptible strain, is now the most common cause of C. difficile infection (CDI) among adults in the USA. Objectives: To identify mechanisms underlying the evolution and transmission of an MDR DH/NAP11/106 clone. Methods: WGS (Illumina MiSeq), restriction endonuclease analysis (REA) and antibiotic susceptibility testing were performed...

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Identifiers

PMID: 29342270
DOI: 10.1093/jac/dkx523
PMCID: PMC6454525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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