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Phylogenomic analysis of Clostridioides difficile ribotype 106 strains reveals novel genetic islands and emergent phenotypes.

Scientific reports - 17 Dec 2020

Roxas Bryan Angelo P, Roxas Jennifer Lising, Claus-Walker Rachel, Harishankar Anusha, Mansoor Asad, Anwar Farhan, Jillella Shobitha, Williams Alison, Lindsey Jason, Elliott Sean P, Shehab Kareem W, Viswanathan V K, Vedantam Gayatri

Abstract excerpt

Clostridioides difficile infection (CDI) is a major healthcare-associated diarrheal disease. Consistent with trends across the United States, C. difficile RT106 was the second-most prevalent molecular type in our surveillance in Arizona from 2015 to 2018. A representative RT106 strain displayed robust virulence and 100% lethality in the hamster model of acute CDI. We identified a unique 46 KB genomic island (GI1)...

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Identifiers

PMID: 33335199
DOI: 10.1038/s41598-020-79123-2
PMCID: PMC7747571

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