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Article

Induction of high tolerance to artemisinin by sub-lethal administration: A new in vitro model of P. falciparum.

PloS one - 1 Jan 2018

De Lucia Serena, Tsamesidis Ioannis, Pau Maria Carmina, Kesely Kristina R, Pantaleo Antonella, Turrini Francesco

Abstract excerpt

Artemisinin resistance is a major threat to malaria control efforts. Resistance is characterized by an increase in the Plasmodium falciparum parasite clearance half-life following treatment with artemisinin-based combination therapies (ACTs) and an increase in the percentage of surviving parasites. The remarkably short blood half-life of artemisinin derivatives may contribute to drug-resistance, possibly through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29342187
DOI: 10.1371/journal.pone.0191084
PMCID: PMC5771598

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