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Article

Investigation of SUMO pathway genes in the etiology of nonsyndromic cleft lip with or without cleft palate.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jun 2012

Carta Eloisa, Pauws Erwin, Thomas Anna C, Mengrelis Konstantinos, Moore Gudrun E, Lees Melissa, Stanier Philip

Abstract excerpt

BACKGROUND: SUMO1 has been implicated as having a role in the causation of cleft lip with or without cleft palate (CLP), both directly and through association studies in humans and, perhaps more controversially, in transgenic mouse studies. METHODS: To screen for sequence variants that might be responsible for human CLP, we performed direct DNA sequence analysis in a well-characterized white European cohort of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22492558
DOI: 10.1002/bdra.23008

Genes

PIAS1
SUMO1
SUMO3
PIAS2
SUMO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigation of SUMO pathway genes in the etiology of nonsyndromic cleft lip with or without cleft palate.PMID 22492558Read ↗

SUMO1 as a candidate gene for non-syndromic cleft lip with or without cleft palate: no evidence for the involvement of common or rare variants in Central European patients.Semantic proximity Read ↗

SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate.Semantic proximity Read ↗

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Candidate Genes for Nonsyndromic Cleft Palate Detected by Exome Sequencing.Semantic proximity Read ↗

Interactions between small ubiquitin-like modifier 1 and nonsyndromic orofacial clefts.Semantic proximity Read ↗

Gene-gene interaction between MSX1 and TP63 in Asian case-parent trios with nonsyndromic cleft lip with or without cleft palate.Semantic proximity Read ↗

Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate.Semantic proximity Read ↗

Testing reported associations of genetic risk factors for oral clefts in a large Irish study population.Semantic proximity Read ↗

[Analysis of the HapMap data on SNPs in SUMO1 and association study of rs7599810 in trios with non-syndromic cleft lip with or without cleft palate].Semantic proximity Read ↗

Novel Protein-Altering Variants in Cleft Genes Transmitted in Families With NSCL±P.Semantic proximity Read ↗

Investigating Single Nucleotide Polymorphisms in the Etiology of Cleft Lip and Cleft Palate in the Polish Population.Semantic proximity Read ↗

Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population.Semantic proximity Read ↗

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