Article
The genetic landscape of choroid plexus tumors in children and adults.
Neuro-oncology - 12 Apr 2021
Thomas Christian, Soschinski Patrick, Zwaig Melissa, Oikonomopoulos Spyridon, Okonechnikov Konstantin, Pajtler Kristian W, Sill Martin, Schweizer Leonille, Koch Arend, Neumann Julia, Schüller Ulrich, Sahm Felix, Rauschenbach Laurèl, Keyvani Kathy, Proescholdt Martin, Riemenschneider Markus J, Segewiß Jochen, Ruckert Christian, Grauer Oliver, Monoranu Camelia-Maria, Lamszus Katrin, Patrizi Annarita, Kordes Uwe, Siebert Reiner, Kool Marcel, Ragoussis Jiannis, Foulkes William D, Paulus Werner, Rivera Barbara, Hasselblatt Martin
Abstract excerpt
BACKGROUND: Choroid plexus tumors (CPTs) are intraventricular brain tumors predominantly arising in children but also affecting adults. In most cases, driver mutations have not been identified, although there are reports of frequent chromosome-wide copy-number alterations and TP53 mutations, especially in choroid plexus carcinomas (CPCs). METHODS: DNA methylation profiling and RNA-sequencing was performed in a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.