Article
Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells
17 Aug 2015
Abstract excerpt
Cell lines have been used for drug discovery as useful models of cancers; however, they do not recapitulate cancers faithfully, especially in the points of rapid growth rate and microenvironment independency. Consequently, the majority of conventional anti-cancer drugs are less sensitive to slow growing cells and do not target microenvironmental support, although most primary cancer cells grow slower than cell...
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