Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein–Expressing Cells

30 Dec 2019

Abstract excerpt

Clinical evidence shows that following initial response to treatment, drug-resistant cancer cells frequently evolve and, eventually, most tumors become resistant to all available therapies. We compiled a focused library consisting of >500 commercially available or newly synthetized 8-hydroxyquinoline (8OHQ) derivatives whose toxicity is paradoxically increased rather than decreased by the activity of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Epigenetics and DNA Methylation
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31888888
DOI: 10.1158/0008-5472.can-19-1407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein–Expressing CellsPMID 31888888Read ↗

Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line–Specific Effects from P-Glycoprotein–Induced ToxicitySemantic proximity Read ↗

A clinical-stage oncology compound selectively targets drug-resistant cancersSemantic proximity Read ↗

Dysregulation of cellular iron predisposes chemotherapy resistant cancer cells to ferroptosisSemantic proximity Read ↗

Dysregulation of Labile Iron Predisposes Chemotherapy Resistant Cancer Cells to FerroptosisSemantic proximity Read ↗

New Approaches With Natural Product Drugs for Overcoming Multidrug Resistance in CancerSemantic proximity Read ↗

Isoquinolines alkaloids and cancer metabolism: Pathways and targets to novel chemotherapySemantic proximity Read ↗

Non-oncology drugs are a source of previously unappreciated anti-cancer activitySemantic proximity Read ↗

Innovative therapies for neuroblastoma: The surprisingly potent role of iron chelation in up-regulating metastasis and tumor suppressors and down-regulating the key oncogene, N-mycSemantic proximity Read ↗

The multidrug resistance transporter P-glycoprotein confers resistance to ferroptosis inducersSemantic proximity Read ↗

Gallium(III) Complex with Cloxyquin Ligands Induces Ferroptosis in Cancer Cells and Is a Potent Agent against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma CellsSemantic proximity Read ↗

A “Double-Edged” Scaffold: Antitumor Power within the Antibacterial QuinoloneSemantic proximity Read ↗

Fighting metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux by mitochondria-targeting AIEgensSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.