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Article

Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains.

Journal of neurology, neurosurgery, and psychiatry - 1 Aug 2018

Keogh Michael J, Wei Wei, Aryaman Juvid, Wilson Ian, Talbot Kevin, Turner Martin R, McKenzie Chris-Anne, Troakes Claire, Attems Johannes, Smith Colin, Al Sarraj Safa, Morris Chris M, Ansorge Olaf, Pickering-Brown Stuart, Jones Nick, Ironside James W, Chinnery Patrick F

Abstract excerpt

BACKGROUND: Several studies suggest that multiple rare genetic variants in genes causing monogenic forms of neurodegenerative disorders interact synergistically to increase disease risk or reduce the age of onset, but these studies have not been validated in large sporadic case series. METHODS: We analysed 980 neuropathologically characterised human brains with Alzheimer's disease (AD), Parkinson's...

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Source

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Identifiers

PMID: 29332010
DOI: 10.1136/jnnp-2017-317234
PMCID: PMC6204946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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