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Article

Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease

10 Apr 2018

Abstract excerpt

Background: The prevalence of dementia in Parkinson disease (PD) increases dramatically with advancing age, approaching 80% in patients who survive 20 years with the disease. Increasing evidence suggests a clinical, pathological and genetic overlap between Alzheimer disease, dementia with Lewy bodies and frontotemporal dementia with PD. However, the contribution of the dementia-causing genes to PD risk, cognitive...

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PMID: 29692703
DOI: 10.3389/fnins.2018.00230

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