Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients.

doi:10.1158/1078-0432.CCR-17-2344

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Article

Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2018

Greif Philipp A, Hartmann Luise, Vosberg Sebastian, Stief Sophie M, Mattes Raphael, Hellmann Ines, Metzeler Klaus H, Herold Tobias, Bamopoulos Stefanos A, Kerbs Paul, Jurinovic Vindi, Schumacher Daniela, Pastore Friederike, Bräundl Kathrin, Zellmeier Evelyn, Ksienzyk Bianka, Konstandin Nikola P, Schneider Stephanie, Graf Alexander, Krebs Stefan, Blum Helmut, Neumann Martin, Baldus Claudia D, Bohlander Stefan K, Wolf Stephan, Görlich Dennis, Berdel Wolfgang E, Wörmann Bernhard J, Hiddemann Wolfgang, Spiekermann Karsten

Abstract excerpt

Purpose: To study mechanisms of therapy resistance and disease progression, we analyzed the evolution of cytogenetically normal acute myeloid leukemia (CN-AML) based on somatic alterations.Experimental Design: We performed exome sequencing of matched diagnosis, remission, and relapse samples from 50 CN-AML patients treated with intensive chemotherapy. Mutation patterns were correlated with clinical...

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PMID: 29330206
DOI: 10.1158/1078-0432.CCR-17-2344

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