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Article

Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer

8 Jan 2018

Abstract excerpt

BACKGROUND: Dysregulation of hedgehog pathway is observed in numerous cancers. Relevance of hedgehog pathway genes in cancer cohort and inhibition of its downstream effector (GLI1) towards metastasis in cell lines are explored in the study. METHOD: One hundred fifty fresh tumours of breast cancer patients were collected for the study. Based on differential expression, panel of 6 key regulators of the pathway...

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PMID: 29329585
DOI: 10.1186/s12964-017-0213-y

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