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Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration

5 Jan 2018

Abstract excerpt

Contradictory data have been presented regarding the implication of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome in age-related macular degeneration (AMD), the leading cause of vision loss in the Western world. Recognizing that antibody specificity may explain this discrepancy and in line with recent National Institutes of Health (NIH) guidelines requiring authentication of key...

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PMID: 29323137
DOI: 10.1038/s41598-017-17634-1

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