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Article

Productive replication of Vif-chimeric HIV-1 in feline cells.

Journal of virology - 1 Jul 2010

Stern Melissa A, Hu Chunling, Saenz Dyana T, Fadel Hind J, Sims Olivia, Peretz Mary, Poeschla Eric M

Abstract excerpt

Nonprimate animal models of HIV-1 infection are prevented by missing cellular cofactors and by antiviral actions of species-specific host defense factors. These blocks are profound in rodents but may be less abundant in certain Carnivora. Here, we enabled productive, spreading replication and passage of HIV-1 in feline cells. Feline fibroblasts, T-cell lines, and primary peripheral blood mononuclear cells...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Leukocytes, Mononuclear

Share to vif Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 20463079
DOI: 10.1128/JVI.00584-10
PMCID: PMC2898257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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