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Article

Evolutionary toxicogenomics: diversification of the Cyp12d1 and Cyp12d3 genes in Drosophila species.

Journal of molecular evolution - 1 Jun 2012

McDonnell Cynthia M, King Darrin, Comeron Josep M, Li Hongmei, Sun Weilin, Berenbaum May R, Schuler Mary A, Pittendrigh Barry R

Abstract excerpt

Gene duplication and divergence are overwhelmingly considered to be the primary mechanisms by which cytochrome P450 monooxygenases (P450s) have radiated into a large and diverse gene superfamily. To address how environmental stress drives the fixation and diversification of gene duplications, we have analyzed Cyp12d1 and Cyp12d3, a pair of duplicated genes found in the sequenced Drosophila genomes of the...

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PMID: 22811321
DOI: 10.1007/s00239-012-9506-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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