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Evolution of detoxifying systems: the role of environment and population history in shaping genetic diversity at human CYP2D6 locus.

Pharmacogenetics and genomics - 1 Aug 2010

Fuselli Silvia, de Filippo Cesare, Mona Stefano, Sistonen Johanna, Fariselli Piero, Destro-Bisol Giovanni, Barbujani Guido, Bertorelle Giorgio, Sajantila Antti

Abstract excerpt

OBJECTIVE: The transition from food collection to food production (FP) modified the nature of selective pressures, and several studies illustrate that genetic adaptation to new lifestyle has occurred in humans since the agricultural revolution. Here we test the hypothesis that high levels of genetic variation at CYP2D6, a locus coding for a detoxifying enzyme of the cytochrome P450 complex, reflect this change....

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PMID: 20520586
DOI: 10.1097/FPC.0b013e32833bba25

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