Article

Molecular physiology of pumiliotoxin sequestration in a poison frog

2020-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Poison frogs bioaccumulate alkaloids for chemical defense from their arthropod diet. Although many alkaloids are accumulated without modification, some poison frog species can metabolize pumiliotoxin (PTX 251D ) into the more potent allopumiliotoxin (aPTX 267A ). Despite extensive research characterizing the chemical arsenal of poison frogs, the physiological mechanisms involved in the sequest...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59c45107-061f-5dbd-b0e6-b778eed26324
DOI: 10.1101/2020.11.03.367524

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular physiology of pumiliotoxin sequestration in a poison frogDOI 10.1101/2020.11.03.367524Read

Discovering venom-derived drug candidates using differential gene expressionSemantic proximity Read

The function and evolutionary significance of a triplicated Na,K-ATPase gene in a toxin-specialized insect.Semantic proximity Read

Passive accumulation of alkaloids in inconspicuously colored frogs refines the evolutionary paradigm of acquired chemical defenses.Semantic proximity Read

Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugsSemantic proximity Read

Eco-Metabolomics Applied to the Chemical Ecology of Poison Frogs (Dendrobatoidea)Semantic proximity Read

Integrative Inducer Intervention and Transcriptomic Analyses Reveal the Metabolism of Paralytic Shellfish Toxins in Azumapecten farreriSemantic proximity Read

Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire.Semantic proximity Read

PharmGKB summary: venlafaxine pathway.Semantic proximity Read

Specific phytochemicals in floral nectar up‐regulate genes involved in longevity regulation and xenobiotic metabolism, extending mosquito life spanSemantic proximity Read

Predose blood gene expression profiles might identify the individuals susceptible to carbon tetrachloride-induced hepatotoxicity.Semantic proximity Read

Transcriptome profiling of Rhipicephalus annulatus reveals differential gene expression of metabolic detoxifying enzymes in response to acaricide treatmentSemantic proximity Read

Blood transcriptome responses to PFOA and GenX treatment in the marsupial biomedical model Monodelphis domesticaSemantic proximity Read