Genomic evolution of uveal melanoma arising in ocular melanocytosis.

doi:10.1101/mcs.a004051

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Article

Genomic evolution of uveal melanoma arising in ocular melanocytosis.

Cold Spring Harbor molecular case studies - 1 Aug 2019

Durante Michael A, Field Matthew G, Sanchez Margaret I, Covington Kyle R, Decatur Christina L, Dubovy Sander R, Harbour J William

Abstract excerpt

Ocular melanocytosis is the most important predisposing condition for the eye cancer uveal melanoma (UM). Here, we present a patient who developed UM arising within ocular melanocytosis who was treated with enucleation (eye removal), which provided an invaluable opportunity to interrogate both the UM and adjacent uveal tissue containing the melanocytosis using whole-exome and deep-targeted sequencing. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 31186267
DOI: 10.1101/mcs.a004051
PMCID: PMC6672022

Genes

PLCB4
BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.