Article
Pde6brd1 mutation modifies cataractogenesis in Foxe3rct mice.
Biochemical and biophysical research communications - 29 Jan 2018
Wada Kenta, Saito Junichi, Yamaguchi Midori, Seki Yuta, Furugori Masamune, Takahashi Gou, Nishito Yasumasa, Matsuda Hiroshi, Shitara Hiroshi, Kikkawa Yoshiaki
Abstract excerpt
The Foxe3rct mutation, which causes early-onset cataracts, is a recessive mutation found in SJL/J mice. A previous study reported that cataract phenotypes are modified by the genetic background of mouse inbred strains and that the Pde6brd1 mutation, which induced degeneration of the photoreceptor cells, is a strong candidate genetic modifier to accelerate the severity of cataractogenesis of Foxe3rct mice. We...
Topics
- Animals
- Cataract
- Cyclic Nucleotide Phosphodiesterases, Type 6
- Disease Progression
- Forkhead Transcription Factors
- Genetic Predisposition to Disease
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Structure-Activity Relationship