Article
Fine localization of a new cataract locus, Kec, on mouse chromosome 14 and exclusion of candidate genes as the gene that causes cataract in the Kec mouse.
BMB reports - 30 Sept 2008
Kang Minji, Cho Jae-Woo, Kim Jeong Ki, Kim Eunmin, Kim Jae-Young, Cho Kyu-Hyuk, Song Chang-Woo, Yoon Sungjoo Kim
Abstract excerpt
A mouse with cataract, Kec, was generated from N-ethyl-N-nitrosourea (ENU) mutagenesis. Cataract in the Kec mouse was observable at about 5 weeks after birth and this gradually progressed to become completely opaque by 12 weeks. Dissection microscopy revealed that vacuoles with a radial or irregular shape were located primarily in the cortex of the posterior and equatorial regions of the lens. At the late stage,...
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