Article
Genetic analysis of Nakano Cataract and its modifier genes in mice.
Experimental eye research - 1 Dec 2002
Narita Makiko, Wang Yun, Kita Akiyo, Omi Natsue, Yamada Yoshihiro, Hiai Hiroshi
Abstract excerpt
The Nakano Cataract (NCT) is an autosomal, recessive, single gene mutation in mice leading to an osmotic cataract induced by an endogenous inhibitor of Na, K-ATPase. In this report, we further refined the map position of the mutant locus to a <0.7c M segment between D16Mit5 and D16Mit185 in 1,000 BALB/c-nct/nct x(BALB/c- nct/nctxMSM)F1 backcrossed mice with PCR-based microsatellite analysis. The NCT in the...
Topics
- Animals
- Cataract
- Chromosome Mapping
- Crosses, Genetic
- Crystallins
- Disease Models, Animal
- Electrophoresis, Polyacrylamide Gel
- Genes, Recessive
- Genetic Linkage
- Haplotypes
- Mice
- Mice, Inbred BALB C
- Microsatellite Repeats
- Mutation