Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A comparative analysis of recombinant Fab and full‐length antibody production in Chinese hamster ovary cells

29 Sept 2021

Abstract excerpt

Monoclonal antibodies are the leading class of biopharmaceuticals in terms of numbers approved for therapeutic purposes. Antigen-binding fragments (Fab) are also used as biotherapeutics and used widely in research applications. The dominant expression systems for full-length antibodies are mammalian cell-based, whereas for Fab molecules the preference has been an expression in bacterial systems. However, advances...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Monoclonal and Polyclonal Antibodies Research
Share to Protein purification and stability
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34585737
DOI: 10.1002/bit.27944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A comparative analysis of recombinant Fab and full‐length antibody production in Chinese hamster ovary cellsPMID 34585737Read ↗

Advances in recombinant antibody manufacturingSemantic proximity Read ↗

Strategies and Considerations for Improving Recombinant Antibody Production and Quality in Chinese Hamster Ovary CellsSemantic proximity Read ↗

Enhancing recombinant antibody yield in Chinese hamster ovary cellsSemantic proximity Read ↗

Utilizing non-clonal CHO cell derived materials for preclinical studies of complex moleculesSemantic proximity Read ↗

Techno-Economic Assessment of Cell-Free Synthesis of Monoclonal Antibodies Using CHO Cell ExtractsSemantic proximity Read ↗

Rapid high-throughput cloning and stable expression of antibodies in HEK293 cellsSemantic proximity Read ↗

Bioreactor scale up and protein product quality characterization of piggyBac transposon derived CHO poolsSemantic proximity Read ↗

RNA‐Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO CellsSemantic proximity Read ↗

Surface display vectors for selective detection and isolation of high level antibody producing cellsSemantic proximity Read ↗

Antibody Production Techniques and Antibody Types: Evolution, Methodologies, and ApplicationsSemantic proximity Read ↗

Development of a CHO-Based Cell-Free Platform for Synthesis of Active Monoclonal AntibodiesSemantic proximity Read ↗

Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-CloningSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.