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Article

Reduced CDHR3 expression in children wheezing with rhinovirus.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Mar 2018

Stenberg Hammar Katarina, Niespodziana Katarzyna, van Hage Marianne, Kere Juha, Valenta Rudolf, Hedlin Gunilla, Söderhäll Cilla

Abstract excerpt

BACKGROUND: Rhinovirus-induced wheezing in young children has been associated with increased asthma risk at school age. Recently, the transmembrane protein cadherin-related family member 3 (CDHR3) was identified as the RV-C receptor and the genetic variant rs6967330 (p.Cys529Tyr) was reported to be associated with enhanced RV-C binding and increased replication in vitro. The aim of this study was to examine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29314338
DOI: 10.1111/pai.12858

Genes

CDHR3

Variants

rs6967330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Reduced CDHR3 expression in children wheezing with rhinovirus.PMID 29314338Read ↗

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Association between cadherin-related family member 3 rs6967330-A and human rhinovirus-C induced wheezing in childrenSemantic proximity Read ↗

Genetic impact of CDHR3 on the adult onset of asthma and COPD.Semantic proximity Read ↗

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Associations between genetic variants in the 17q21 locus, CDHR3 and childhood asthmaSemantic proximity Read ↗

CDHR3 extracellular domains EC1-3 mediate rhinovirus C interaction with cells and as recombinant derivatives, are inhibitory to virus infectionSemantic proximity Read ↗

Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbationsSemantic proximity Read ↗

Association of Asthma Risk Alleles With Acute Respiratory Tract Infections and Wheezing Illnesses in Young Children.Semantic proximity Read ↗

The rs6967330 minor allele in CDHR3 is a significant risk factor for severe acute exacerbations in chronic rhinosinusitis.Semantic proximity Read ↗

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