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Article

Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication.

Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 2015

Bochkov Yury A, Watters Kelly, Ashraf Shamaila, Griggs Theodor F, Devries Mark K, Jackson Daniel J, Palmenberg Ann C, Gern James E

Abstract excerpt

Members of rhinovirus C (RV-C) species are more likely to cause wheezing illnesses and asthma exacerbations compared with other rhinoviruses. The cellular receptor for these viruses was heretofore unknown. We report here that expression of human cadherin-related family member 3 (CDHR3) enables the cells normally unsusceptible to RV-C infection to support both virus binding and replication. A coding single...

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Source

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Identifiers

PMID: 25848009
DOI: 10.1073/pnas.1421178112
PMCID: PMC4418890

Genes

CDHR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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