The rs6967330 minor allele in CDHR3 is a significant risk factor for severe acute exacerbations in chronic rhinosinusitis.

doi:10.1016/j.jaci.2024.09.025

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Article

The rs6967330 minor allele in CDHR3 is a significant risk factor for severe acute exacerbations in chronic rhinosinusitis.

The Journal of allergy and clinical immunology - 1 Feb 2025

Palumbo Sunny, Irish Joseph, Narendran Nirushan, Stern Debra A, Volpe Sophia, Le Christopher H, Starks Rebekah, Bosco Anthony, Martinez Fernando D, Chang Eugene H

Abstract excerpt

BACKGROUND: Acute exacerbations of chronic rhinosinusitis (AECRS) are commonly triggered by rhinovirus (RV) infections with secondary bacterial infections. Risk factors for AECRS are not well understood. OBJECTIVE: We sought to determine whether carriers of the minor allele rs6967330 (AA/AG) in the cadherin-related family member 3 (CDHR3) gene have an increased risk for RV infections in AECRS in vivo and identify...

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Identifiers

PMID: 39389125
DOI: 10.1016/j.jaci.2024.09.025
PMCID: PMC11805668

Genes

CDHR3

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