The role of CDHR3 in susceptibility to otitis media.

doi:10.1007/s00109-021-02118-7

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Article

The role of CDHR3 in susceptibility to otitis media.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2021

Hirsch Scott D, Elling Christina L, Bootpetch Tori C, Scholes Melissa A, Hafrén Lena, Streubel Sven-Olrik, Pine Harold S, Wine Todd M, Szeremeta Wasyl, Prager Jeremy D, Einarsdottir Elisabet, Yousaf Ayesha, Baschal Erin E, Rehman Sakina, Bamshad Michael J, Nickerson Deborah A, Riazuddin Saima, Leal Suzanne M, Ahmed Zubair M, Yoon Patricia J, Kere Juha, Chan Kenny H, Mattila Petri S, Friedman Norman R, Chonmaitree Tasnee, Frank Daniel N, Ryan Allen F, Santos-Cortez Regie Lyn P

Abstract excerpt

Otitis media (OM) is common in young children and can cause hearing loss and speech, language, and developmental delays. OM has high heritability; however, little is known about OM-related molecular and genetic processes. CDHR3 was previously identified as a locus for OM susceptibility, but to date, studies have focused on how the CDHR3 p.Cys529Tyr variant increases epithelial binding of rhinovirus-C and risk for...

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PMID: 34322716
DOI: 10.1007/s00109-021-02118-7
PMCID: PMC8541908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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