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Article

Estimating TP53 Mutation Carrier Probability in Families with Li-Fraumeni Syndrome Using LFSPRO.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2017

Peng Gang, Bojadzieva Jasmina, Ballinger Mandy L, Li Jialu, Blackford Amanda L, Mai Phuong L, Savage Sharon A, Thomas David M, Strong Louise C, Wang Wenyi

Abstract excerpt

Background: Li-Fraumeni syndrome (LFS) is associated with germline TP53 mutations and a very high lifetime cancer risk. Algorithms that assess a patient's risk of inherited cancer predisposition are often used in clinical counseling. The existing LFS criteria have limitations, suggesting the need for an advanced prediction tool to support clinical decision making for TP53 mutation testing and LFS...

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Source

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Identifiers

PMID: 28137790
DOI: 10.1158/1055-9965.EPI-16-0695
PMCID: PMC5457344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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