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Article

Prenatal diagnosis in Li-Fraumeni syndrome.

Journal of pediatric hematology/oncology - 1 Sept 2004

Avigad Smadar, Peleg Dan, Barel Dalit, Benyaminy Hadar, Ben-Baruch Noa, Taub Ellen, Shohat Mordechai, Goshen Yacov, Cohen Ian J, Yaniv Isaac, Zaizov Rina

Abstract excerpt

PURPOSE: The hallmark of Li-Fraumeni syndrome (LFS), a familial cancer syndrome, is constitutional TP53 mutation. The authors addressed the complex question of predictive prenatal genetic testing for cancer risk associated with inheritance of TP53 mutation. METHODS: A classic LFS family including the proband (a 20-month-old boy with rhabdomyosarcoma), his 36-year-old father with osteosarcoma, and his 40-year-old...

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Source

Identifiers

PMID: 15342977
DOI: 10.1097/01.mph.0000139452.45209.ad

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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