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Article

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI.

Human molecular genetics - 15 Oct 2003

Huynh Duong P, Scoles Daniel R, Nguyen Dung, Pulst Stefan M

Abstract excerpt

Inactivating mutations of the gene encoding parkin are responsible for some forms of autosomal recessive juvenile Parkinson disease. Parkin is a ubiquitin ligase that ubiquitinates misfolded proteins targeted for the proteasome-dependent protein degradation pathway. Using the yeast two-hybrid sys...

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PMID: 12925569
DOI: 10.1093/hmg/ddg269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12925569-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI.PMID 12925569Read ↗

Screening for mutations in synaptotagmin XI in Parkinson's disease.Semantic proximity Read ↗

Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1Semantic proximity Read ↗

Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.Semantic proximity Read ↗

The synaptic function of parkin.Semantic proximity Read ↗

The role of parkin in familial and sporadic Parkinson's disease.Semantic proximity Read ↗

Parkinson's disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons.Semantic proximity Read ↗

Profiling of Parkin-Binding Partners Using Tandem Affinity PurificationSemantic proximity Read ↗

Parkin and Parkinsonʼs diseaseSemantic proximity Read ↗

Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson diseaseSemantic proximity Read ↗

SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila.Semantic proximity Read ↗

SH3 Domains from a Subset of BAR Proteins Define a Ubl-Binding Domain and Implicate Parkin in Synaptic UbiquitinationSemantic proximity Read ↗

Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.Semantic proximity Read ↗

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