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Article

Evaluation of CpxRA as a Therapeutic Target for Uropathogenic Escherichia coli Infections.

Infection and immunity - 1 Mar 2018

Dbeibo Lana, van Rensburg Julia J, Smith Sara N, Fortney Kate R, Gangaiah Dharanesh, Gao Hongyu, Marzoa Juan, Liu Yunlong, Mobley Harry L T, Spinola Stanley M

Abstract excerpt

CpxRA is an envelope stress response system found in all members of the family Enterobacteriaceae; CpxA has kinase activity for CpxR and phosphatase activity for phospho-CpxR, a transcription factor. CpxR also accepts phosphate groups from acetyl phosphate, a glucose metabolite. Activation of CpxR increases the transcription of genes encoding membrane repair and downregulates virulence determinants. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29311237
DOI: 10.1128/IAI.00798-17
PMCID: PMC5820967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Evaluation of CpxRA as a Therapeutic Target for Uropathogenic Escherichia coli Infections.PMID 29311237Read ↗

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