Article

Conserved Metabolic Regulator ArcA Responds to Oxygen Availability, Iron Limitation, and Cell Envelope Perturbations during Bacteremia

2023-04-18

Abstract excerpt

<h4>ABSTRACT</h4> Bacteremia, a systemic infection associated with severe clinical outcomes, is often caused by Gram-negative facultative anaerobes. ArcAB, a two-component regulatory system that represses aerobic respiration, is a key mediator of metabolic adaptation for such bacteria. Using targeted mutational analysis informed by global genetic screens, we identified the arcA gene as promoting fitness of Kleb...

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Literature Corpus work: 3b4220bd-ff5d-5a77-a043-ab603f174cf7
DOI: 10.1101/2023.04.18.537286

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Conserved Metabolic Regulator ArcA Responds to Oxygen Availability, Iron Limitation, and Cell Envelope Perturbations during BacteremiaDOI 10.1101/2023.04.18.537286Read

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